Project MKULTRA was a mind control research operation carried out in the United States (as well as other countries like Canada) by the CIA. MKULTRA conducted many different illegal experiments on US and Canadian patients without them knowing exactly what was being done or why. Many of the experiments were so bad that much of the experimentation was done in Canada and other foreign countries to escape United States jurisdiction. The project started in 1950 and lasted until around 1973.

Experiments conducted on unwitting humans and children included things like: torture, verbal and sexual abuse, electrical and chemical shock, the effects of stress on humans, interrogation techniques, subsonic and vibrational disorientation, drugs, radiation, genetic research, brainwashing, the use of prostitutes by agents, gases and poisons.