《1855 American Tycoon》Chapter 58: Drug Experiment
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In the laboratory, Scrooge hastily used dozens of rabbits to verify the effectiveness of his sulfa and found that it was indeed very effective in killing bacteria, and the rabbits were still alive and well after using the drug.
"Boss, do you see something wrong with these two rabbits?" The lab technician Hanks knew more about the safety of the drug than Scrooge did, so he rushed to remind Scrooge, who was about to fill in the "no significant toxic side effects" column on the study report.
"Oh, you see they are not alive and well?" Scrooge said, unconcerned.
Of course, Scrooge knew what was going on. It was a typical reaction to sulfonamide allergy. Like other antibiotics, sulfonamide can also have an allergic reaction. And compared to penicillin and other things, sulfonamide allergies are harder to detect in advance. The good thing is that the severity of allergic reactions to sulfonamides is much milder than that of penicillin and other things, which are just skin reactions and lung reactions. Well, that is, some drug rash and a bit of asthma, although in severe cases it can also lead to shock, the chance of this is very low. Generally speaking, sulfa allergies don't kill people.
Hanks was a new immigrant who, by his own account, had studied at the University of Hamburg's chemistry department. However, he did not have a diploma, because he violated the operating procedures of the laboratory, private experiments on their own were found, and the result was expelled.
Scrooge did not know whether Hanks was telling the truth or not, but he asked Hanks a few questions, and lets him carry out the experimental operation, found that Hanks was indeed trained in this area, so he retained this guy. Of course, Scrooge wouldn't pay him the salary of a college student.
Hanks grabbed the two rabbits out of their cages and took a serious look at them.
"Boss, these two rabbits have some herpes on their skin, especially on their mouths and anuses."
This is a typical symptom of a sulfa drug allergy. Scrooge nodded and said, "Stop medicating these two rabbits, give them plenty of water, and then see what happens. Well, Hanks, I'll leave that to you."
A week later, Hanks came to report, "Boss, the two rabbits are all right."
"Oh, I see. Where are the other rabbits?" Scrooge asked without looking up.
"They're all fine," Hanks replied.
"Well, let's haul all those rabbits back to the market and sell them to recover the cost. Also, get ready and we'll all go to the hospital tomorrow for the clinical trial."
"So soon! Biological experiments have just finished ......" Hanks felt that the haphazard biological experiments are not even all completed.
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"Because a few septic patients are already dying, if not, they will have to go to God." Scrooge said, "anyway, they have no cure, just waiting to die, even if our drugs have problems, for them, can still be bad to get there?"
......
The nineteenth-century hospital was still a place where ghosts were hated, not only because, in the days before antibiotics were discovered, doctors did not have any particularly effective methods for many illnesses. It is also because, at that time, people did not even know the relationship between bacteria and disease, as for sterilization and sterilization, of course, it is impossible to talk about. A scalpel, after dissecting the body of a patient who had died of tetanus, was used to operate on another patient who was still alive (in fact, already dead), and the sheet that had just been placed under a patient who had died of cholera was laid on the bed of another patient without even being washed. The patient in the hospital, not only can not get effective treatment but will also be infected with each other, the result of the vertical into the hospital, the horizontal carry out became the hospital's norm. In obstetrics and gynecology, for example, for most of the nineteenth century, the mortality rate of pregnant women giving birth in hospitals was more than ten to one hundred times higher than the mortality rate of their births at home. Deaths from bacterial infections after delivery were even comparable to those from cholera. Patients and their families know this. Therefore, patients who are admitted to hospitals are either very sick and dying or have infectious diseases. Many people were sent to the hospital before their families had organized their funerals in advance. If there were any advantages of the nineteenth-century hospital, the only benefit was probably the absence of the doctor's alarm. It was a social consensus that hospitalization was equivalent to death.
A few days ago, Scrooge's men came to this Baptist charity hospital called "Salvation" and explained to the director that they had a new drug for sepsis that had worked very well in animal studies, and they wanted to get a few patients with sepsis to test it out in this hospital.
If this kind of thing is placed in the 21st century, it is a very troublesome thing. The hospital director would not have approved such a businessman without any qualifications to come to the hospital to test any new drug. However, the good thing is that this is still the 19th century, and there is no strict quality management system at all, as long as the patient or the patient's family signs the paper, there is no one to care. Not to mention this is also a lovely charity hospital. The so-called charity hospitals are generally "free" hospitals run by churches or other organizations. Patients who come to such hospitals for treatment generally have two characteristics: first, they have no money; second, they are hopeless. Convincing such patients to sign a voluntary trial of a new drug that could save their lives is simply a simple matter.
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As a free charitable hospital, "Save Grace" hospital is very small, its entire campus is an old warehouse, and outpatient clinics, wards, operating rooms, and other things are in that large warehouse inside. Because the hospital was converted from a warehouse, the lighting conditions were very poor. So that when Scrooge and a few assistants, under the protection of several Blackwater security guards (no way, the hospital is in a slum area, the security here has always been very chaotic) after entering through the hospital doors, eyes half a day did not adapt to it.
After a while, Shi Gaozhi could see the situation inside the hospital: several beds were placed horizontally and vertically in the dark corners, yellowing sheets with old black blood stains. All kinds of dirty things were piled up on the floor, and swarms of green-headed flies were buzzing there. A cloth curtain simply partitioned off the operating room.
"Hello, Mr. Scrooge, I'm Heathfield, the hospital director." A little old man held out his hand to Scrooge, well, the hand seems to have not scrubbed clean blood or something else.
The company's main business is to provide a wide range of products and services to the public.
"The first thing you need to do is to get your hands on a new one. This is a petri dish for all kinds of pathogenic bacteria! And look at your hand, God knows what's on it. I'd be stupid to shake your hand!" That's what Scrooge thought.
Seeing Scrooge's actions, the director was not too embarrassed, because he also realized that his hands were a little too dirty. So he wiped his hands on his apron casually and said to Scrooge: "Sorry, I just finished delivering a woman, I haven't had time to ......".
Because Scrooge promised to give this hospital a little donation, the hospital director appeared extra attentive, he told Scrooge, in this hospital, there are now four patients with various reasons appear sepsis symptoms, after learning that a drug may be able to save their lives, are willing to accept treatment.
"Well, let's have them sign the authorization form," Scrooge said he didn't want to spend a minute in the place. The air in this place is full of all kinds of germs and it is too dangerous.
The director came to the bedside with a few people, and Scrooge's attendant took out the authorization agreement from his purse, which would have been a typical illegal agreement in later times. The reason is that it deprives the patient of almost any rights, and according to it, no matter what happens to the patient afterward, they will not be held responsible. When the attorney that Scrooge hired drew up the agreement for Scrooge, Scrooge was worried about whether it was legal. But the lawyer told him that all such agreements are like that. It was legal. So Scrooge heartily exclaimed, "This is a golden age for the rich!"
The patients who were so close to being called by the Lord would not have any objection to this agreement. In fact, at this point, you just hold out a long claw, take out a parchment agreement written with mysterious flaming words and tell them that if they sign it, they will not die, well, many patients will also sign.
Seeing the patient sign, Scrooge instructed Hanks to take out the medicine and give it to the director and gave him the dosage and precautions to take. Scrooge noticed the gleam in the patient's eyes when they saw the glass bottle containing the medicine, which made him a little uncomfortable. "When did I get bored with these NPCs?" The first time I saw the NPCs, I thought.
......
After walking out of the hospital, Scrooge got into the carriage without saying a word, and Hanks sat next to him.
"Hanks, just got out of the hospital, what do you think?" Scrooge said.
"It was horrible! People who are not sick are going to die of illness there. If I ever get sick, I'd rather put a bullet in my head than sleep in that filthy place."
"That's not how rich people's hospitals work, Hanks. In this world, heaven and hell are real. If you have money, you live in heaven, if you don't, you're in hell. Earn your money!" Scrooge said.
"You're right, boss, I must work hard to earn more money and live a good life." Hanks thought Scrooge was encouraging him, so he replied. He did not know that Scrooge's words were more for his ears.
......
Perhaps because the germs of this era are still very pure, have not been a variety of chemical weapons called antibiotics and biological weapons poisoning, so there is no time to produce resistance to such things. Therefore, the effect of these drugs is amazing, according to the news from the "salvation" hospital, only after a week of treatment, the four patients have gradually recovered. It seems that the trial can be expanded. And the time to finally put this drug on the market should not be far away.
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