For twenty years Terra suffered endless torment, death infiltrated every nook and cranny of the once beautiful planet. Under the tyranny of a mad king, the Southern Continent declared war on all who opposed its treachery; leaving in its wake, two decades of blood shed.

Under the threat of extinction, man was compelled to make advancements in technology, several research units and groups were commissioned. Included in the most vital research programmes was one of the earliest programmes to be commissioned, the Personality and Neural Enchancement Programme (PNE). The programme promised heightened sensory and intellectual abilities, it was a race against time to vindicate mankind.

Pain, an orphaned baby on the brink of death, obtained salvation in the PNE programme. However, before the programme was shut down, the lead researcher, Dr. Dante Bell mysteriously disappeared along with Pain. 

17 years later, Pain and Dr. Bell make their majestic appearance, albeit under new identities, leading to a chain of events that will forever change the course of mankind's destiny!